Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes. Roles of xanthine oxidase and mitochondrial injury. [electronic resource]
Producer: 20041110Description: 454-63 p. digitalISSN:- 0168-8278
- Adenosine Triphosphate -- metabolism
- Allopurinol -- pharmacology
- Animals
- Antioxidants -- pharmacology
- Azathioprine -- administration & dosage
- Cell Differentiation
- Cell Survival
- Cells, Cultured
- Chromans -- pharmacology
- Enzyme Inhibitors -- pharmacology
- Glutathione -- metabolism
- Glutathione Disulfide -- metabolism
- Hepatocytes -- drug effects
- Male
- Mercaptopurine -- administration & dosage
- Microscopy, Electron
- Mitochondria, Liver -- metabolism
- Necrosis
- Oxidative Stress
- Rats
- Rats, Wistar
- Time Factors
- Xanthine Oxidase -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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