Results
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1.
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Synthesis of the thapsigargins. [electronic resource] by
- Ley, Steven V
- Antonello, Alessandra
- Balskus, Emily P
- Booth, David T
- Christensen, Søren B
- Cleator, Ed
- Gold, Helen
- Högenauer, Klemens
- Hünger, Udo
- Myers, Rebecca M
- Oliver, Steven F
- Simic, Oliver
- Smith, Martin D
- Søhoel, Helmer
- Woolford, Alison J A
Producer: 20040923
In:
Proceedings of the National Academy of Sciences of the United States of America vol. 101
Availability: No items available.
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2.
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Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency. [electronic resource] by
- Murray, Christopher W
- Carr, Maria G
- Callaghan, Owen
- Chessari, Gianni
- Congreve, Miles
- Cowan, Suzanna
- Coyle, Joseph E
- Downham, Robert
- Figueroa, Eva
- Frederickson, Martyn
- Graham, Brent
- McMenamin, Rachel
- O'Brien, M Alistair
- Patel, Sahil
- Phillips, Theresa R
- Williams, Glyn
- Woodhead, Andrew J
- Woolford, Alison J-A
Producer: 20100916
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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3.
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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. [electronic resource] by
- Chessari, Gianni
- Buck, Ildiko M
- Day, James E H
- Day, Philip J
- Iqbal, Aman
- Johnson, Christopher N
- Lewis, Edward J
- Martins, Vanessa
- Miller, Darcey
- Reader, Michael
- Rees, David C
- Rich, Sharna J
- Tamanini, Emiliano
- Vitorino, Marc
- Ward, George A
- Williams, Pamela A
- Williams, Glyn
- Wilsher, Nicola E
- Woolford, Alison J-A
Producer: 20151116
In:
Journal of medicinal chemistry vol. 58
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4.
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Design and Synthesis of 56 Shape-Diverse 3D Fragments. [electronic resource] by
- Downes, Thomas D
- Jones, S Paul
- Klein, Hanna F
- Wheldon, Mary C
- Atobe, Masakazu
- Bond, Paul S
- Firth, James D
- Chan, Ngai S
- Waddelove, Laura
- Hubbard, Roderick E
- Blakemore, David C
- De Fusco, Claudia
- Roughley, Stephen D
- Vidler, Lewis R
- Whatton, Maria Ann
- Woolford, Alison J-A
- Wrigley, Gail L
- O'Brien, Peter
Producer: 20200722
In:
Chemistry (Weinheim an der Bergstrasse, Germany) vol. 26
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5.
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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA [electronic resource] by
- Woolford, Alison J-A
- Day, Philip J
- Bénéton, Véronique
- Berdini, Valerio
- Coyle, Joseph E
- Dudit, Yann
- Grondin, Pascal
- Huet, Pascal
- Lee, Lydia Y W
- Manas, Eric S
- McMenamin, Rachel L
- Murray, Christopher W
- Page, Lee W
- Patel, Vipulkumar K
- Potvain, Florent
- Rich, Sharna J
- Sang, Yingxia
- Somers, Don O
- Trottet, Lionel
- Wan, Zehong
- Zhang, Xiaomin
Producer: 20170615
In:
Journal of medicinal chemistry vol. 59
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6.
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Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. [electronic resource] by
- Heightman, Tom D
- Callahan, James F
- Chiarparin, Elisabetta
- Coyle, Joseph E
- Griffiths-Jones, Charlotte
- Lakdawala, Ami S
- McMenamin, Rachel
- Mortenson, Paul N
- Norton, David
- Peakman, Torren M
- Rich, Sharna J
- Richardson, Caroline
- Rumsey, William L
- Sanchez, Yolanda
- Saxty, Gordon
- Willems, Henriëtte M G
- Wolfe, Lawrence
- Woolford, Alison J-A
- Wu, Zining
- Yan, Hongxing
- Kerns, Jeffrey K
- Davies, Thomas G
Producer: 20200622
In:
Journal of medicinal chemistry vol. 62
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7.
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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. [electronic resource] by
- Woodhead, Andrew J
- Angove, Hayley
- Carr, Maria G
- Chessari, Gianni
- Congreve, Miles
- Coyle, Joseph E
- Cosme, Jose
- Graham, Brent
- Day, Philip J
- Downham, Robert
- Fazal, Lynsey
- Feltell, Ruth
- Figueroa, Eva
- Frederickson, Martyn
- Lewis, Jonathan
- McMenamin, Rachel
- Murray, Christopher W
- O'Brien, M Alistair
- Parra, Lina
- Patel, Sahil
- Phillips, Theresa
- Rees, David C
- Rich, Sharna
- Smith, Donna-Michelle
- Trewartha, Gary
- Vinkovic, Mladen
- Williams, Brian
- Woolford, Alison J-A
Producer: 20100916
In:
Journal of medicinal chemistry vol. 53
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8.
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Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design. [electronic resource] by
- Wyatt, Paul G
- Woodhead, Andrew J
- Berdini, Valerio
- Boulstridge, John A
- Carr, Maria G
- Cross, David M
- Davis, Deborah J
- Devine, Lindsay A
- Early, Theresa R
- Feltell, Ruth E
- Lewis, E Jonathan
- McMenamin, Rachel L
- Navarro, Eva F
- O'Brien, Michael A
- O'Reilly, Marc
- Reule, Matthias
- Saxty, Gordon
- Seavers, Lisa C A
- Smith, Donna-Michelle
- Squires, Matt S
- Trewartha, Gary
- Walker, Margaret T
- Woolford, Alison J-A
Producer: 20080910
In:
Journal of medicinal chemistry vol. 51
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9.
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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. [electronic resource] by
- Davies, Thomas G
- Wixted, William E
- Coyle, Joseph E
- Griffiths-Jones, Charlotte
- Hearn, Keisha
- McMenamin, Rachel
- Norton, David
- Rich, Sharna J
- Richardson, Caroline
- Saxty, Gordon
- Willems, Henriëtte M G
- Woolford, Alison J-A
- Cottom, Joshua E
- Kou, Jen-Pyng
- Yonchuk, John G
- Feldser, Heidi G
- Sanchez, Yolanda
- Foley, Joseph P
- Bolognese, Brian J
- Logan, Gregory
- Podolin, Patricia L
- Yan, Hongxing
- Callahan, James F
- Heightman, Tom D
- Kerns, Jeffrey K
Producer: 20170718
In:
Journal of medicinal chemistry vol. 59
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10.
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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. [electronic resource] by
- Woolford, Alison J-A
- Pero, Joseph E
- Aravapalli, Sridhar
- Berdini, Valerio
- Coyle, Joseph E
- Day, Philip J
- Dodson, Andrew M
- Grondin, Pascal
- Holding, Finn P
- Lee, Lydia Y W
- Li, Peng
- Manas, Eric S
- Marino, Joseph
- Martin, Agnes C L
- McCleland, Brent W
- McMenamin, Rachel L
- Murray, Christopher W
- Neipp, Christopher E
- Page, Lee W
- Patel, Vipulkumar K
- Potvain, Florent
- Rich, Sharna
- Rivero, Ralph A
- Smith, Kirsten
- Somers, Donald O
- Trottet, Lionel
- Velagaleti, Ranganadh
- Williams, Glyn
- Xie, Ren
Producer: 20170606
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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11.
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Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. [electronic resource] by
- Cho, Young Shin
- Angove, Hayley
- Brain, Christopher
- Chen, Christine Hiu-Tung
- Cheng, Hong
- Cheng, Robert
- Chopra, Rajiv
- Chung, Kristy
- Congreve, Miles
- Dagostin, Claudio
- Davis, Deborah J
- Feltell, Ruth
- Giraldes, John
- Hiscock, Steven D
- Kim, Sunkyu
- Kovats, Steven
- Lagu, Bharat
- Lewry, Kim
- Loo, Alice
- Lu, Yipin
- Luzzio, Michael
- Maniara, Wiesia
- McMenamin, Rachel
- Mortenson, Paul N
- Benning, Rajdeep
- O'Reilly, Marc
- Rees, David C
- Shen, Junqing
- Smith, Troy
- Wang, Yaping
- Williams, Glyn
- Woolford, Alison J-A
- Wrona, Wojciech
- Xu, Mei
- Yang, Fan
- Howard, Steven
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 3
Availability: No items available.
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12.
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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. [electronic resource] by
- Heightman, Tom D
- Berdini, Valerio
- Braithwaite, Hannah
- Buck, Ildiko M
- Cassidy, Megan
- Castro, Juan
- Courtin, Aurélie
- Day, James E H
- East, Charlotte
- Fazal, Lynsey
- Graham, Brent
- Griffiths-Jones, Charlotte M
- Lyons, John F
- Martins, Vanessa
- Muench, Sandra
- Munck, Joanne M
- Norton, David
- O'Reilly, Marc
- Palmer, Nick
- Pathuri, Puja
- Reader, Michael
- Rees, David C
- Rich, Sharna J
- Richardson, Caroline
- Saini, Harpreet
- Thompson, Neil T
- Wallis, Nicola G
- Walton, Hugh
- Wilsher, Nicola E
- Woolford, Alison J-A
- Cooke, Michael
- Cousin, David
- Onions, Stuart
- Shannon, Jonathan
- Watts, John
- Murray, Christopher W
Producer: 20190520
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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