Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits. [electronic resource]
Producer: 20110919Description: 6508-17 p. digitalISSN:- 1520-4995
- Animals
- Catalytic Domain
- Enzyme Stability
- Glutamate-Cysteine Ligase -- chemistry
- Glutathione -- biosynthesis
- Homozygote
- Humans
- Kinetics
- Mice
- Models, Biological
- Mutant Proteins -- metabolism
- Mutation -- genetics
- Protein Binding
- Protein Structure, Secondary
- Recombinant Proteins -- metabolism
- Saccharomyces cerevisiae -- metabolism
- Structural Homology, Protein
- Temperature
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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