Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. [electronic resource]
Producer: 20050823Description: 5025-37 p. digitalISSN:- 0022-2623
- Adamantane -- analogs & derivatives
- Animals
- Biological Availability
- Blood Glucose -- analysis
- Diabetes Mellitus, Type 2 -- drug therapy
- Dipeptides -- chemical synthesis
- Dipeptidyl Peptidase 4 -- metabolism
- Glucose Tolerance Test
- Glycine -- analogs & derivatives
- Humans
- Hypoglycemic Agents -- chemical synthesis
- In Vitro Techniques
- Insulin -- blood
- Male
- Mice
- Mice, Obese
- Microsomes, Liver -- metabolism
- Nitriles -- chemical synthesis
- Proline -- analogs & derivatives
- Protease Inhibitors -- chemical synthesis
- Rats
- Rats, Zucker
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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