Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells. [electronic resource]
Producer: 20180416Description: 30483 p. digitalISSN:- 2045-2322
- Adaptor Proteins, Signal Transducing -- genetics
- Animals
- Apoptosis -- drug effects
- Atorvastatin -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Cell Hypoxia -- drug effects
- Cell Line, Tumor
- Cell Nucleus -- drug effects
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Liver Neoplasms -- drug therapy
- Mice, Nude
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Phosphoproteins -- genetics
- Prognosis
- Protein Transport -- drug effects
- Sorafenib
- Transcription Factors
- Xenograft Model Antitumor Assays
- YAP-Signaling Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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