Intradermal delivery of IL-12 naked DNA induces systemic NK cell activation and Th1 response in vivo that is independent of endogenous IL-12 production. [electronic resource]
Producer: 19990909Description: 1943-50 p. digitalISSN:- 0022-1767
- Adjuvants, Immunologic -- administration & dosage
- Animals
- Antibodies, Monoclonal -- pharmacology
- Chemokine CXCL9
- Chemokines, CXC -- biosynthesis
- Cytomegalovirus -- genetics
- Cytotoxicity, Immunologic -- genetics
- DNA, Viral -- administration & dosage
- Female
- Gene Expression Regulation, Viral -- immunology
- Immunosuppressive Agents -- pharmacology
- Injections, Intradermal
- Intercellular Signaling Peptides and Proteins
- Interferon-gamma -- biosynthesis
- Interleukin-12 -- administration & dosage
- Killer Cells, Natural -- immunology
- Kinetics
- Lymphocyte Activation -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Plasmids -- administration & dosage
- Spleen -- immunology
- Th1 Cells -- metabolism
- beta-Galactosidase -- administration & dosage
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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