Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor. [electronic resource]
Producer: 20040924Description: 4483-93 p. digitalISSN:- 0022-2623
- Binding Sites
- Blood-Brain Barrier -- metabolism
- Drug Design
- Enzyme Inhibitors -- chemistry
- Humans
- Models, Molecular
- Phenylethanolamine N-Methyltransferase -- antagonists & inhibitors
- Receptors, Adrenergic, alpha-2 -- metabolism
- Structure-Activity Relationship
- Tetrahydroisoquinolines -- chemical synthesis
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
There are no comments on this title.
Log in to your account to post a comment.