Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. [electronic resource]
Producer: 20171205Description: 46-58 p. digitalISSN:- 1872-7980
- Activating Transcription Factor 4 -- physiology
- Animals
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Colonic Neoplasms -- drug therapy
- Endoplasmic Reticulum Stress
- Female
- HCT116 Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Reactive Oxygen Species -- metabolism
- Sesquiterpenes -- metabolism
- Thioredoxin Reductase 1 -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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