Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. [electronic resource]
Producer: 19980917Description: 3426-34 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Division -- drug effects
- Crystallography, X-Ray
- Drug Design
- Drug Screening Assays, Antitumor
- Escherichia coli -- enzymology
- Folic Acid Antagonists -- chemical synthesis
- Humans
- Liver -- enzymology
- Models, Molecular
- Molecular Structure
- NADP -- chemistry
- Pneumocystis -- enzymology
- Pyridines -- chemistry
- Pyrimidines -- chemistry
- Quinazolines -- chemical synthesis
- Rats
- Structure-Activity Relationship
- Tetrahydrofolate Dehydrogenase -- metabolism
- Toxoplasma -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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