Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis. [electronic resource]
Producer: 20210510Description: 2847-2861 p. digitalISSN:- 1742-4658
- Adenosine Monophosphate -- chemistry
- Amino Acid Sequence
- Animals
- Biological Evolution
- Catalytic Domain
- Crystallography, X-Ray
- Gluconeogenesis
- Glycolysis
- Guanosine Triphosphate -- chemistry
- Humans
- Kinetics
- Leishmania -- enzymology
- Models, Molecular
- Phosphofructokinases -- chemistry
- Protein Conformation
- Species Specificity
- Substrate Specificity
- Trypanosoma brucei brucei -- enzymology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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