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A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction. [electronic resource] by
- McAllister, Laura A
- Bechle, Bruce M
- Dounay, Amy B
- Evrard, Edelweiss
- Gan, Xinmin
- Ghosh, Somraj
- Kim, Ji-Young
- Parikh, Vinod D
- Tuttle, Jamison B
- Verhoest, Patrick R
Producer: 20110818
In:
The Journal of organic chemistry vol. 76
Availability: No items available.
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5.
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PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency. [electronic resource] by
- Dounay, Amy B
- Anderson, Marie
- Bechle, Bruce M
- Evrard, Edelweiss
- Gan, Xinmin
- Kim, Ji-Young
- McAllister, Laura A
- Pandit, Jayvardhan
- Rong, Suobao
- Salafia, Michelle A
- Tuttle, Jamison B
- Zawadzke, Laura E
- Verhoest, Patrick R
Producer: 20130930
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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6.
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Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders. [electronic resource] by
- Verhoest, Patrick R
- Fonseca, Kari R
- Hou, Xinjun
- Proulx-Lafrance, Caroline
- Corman, Michael
- Helal, Christopher J
- Claffey, Michelle M
- Tuttle, Jamison B
- Coffman, Karen J
- Liu, Shenpinq
- Nelson, Frederick
- Kleiman, Robin J
- Menniti, Frank S
- Schmidt, Christopher J
- Vanase-Frawley, Michelle
- Liras, Spiros
Producer: 20130226
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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7.
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Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition. [electronic resource] by
- Chang, Cheng
- Fonseca, Kari R
- Li, Cheryl
- Horner, Weldon
- Zawadzke, Laura E
- Salafia, Michelle A
- Welch, Kathryn A
- Strick, Christine A
- Campbell, Brian M
- Gernhardt, Steve S
- Rong, Haojing
- Sawant-Basak, Aarti
- Liras, Jennifer
- Dounay, Amy
- Tuttle, Jamison B
- Verhoest, Patrick
- Maurer, Tristan S
Producer: 20190322
In:
Molecular pharmacology vol. 94
Availability: No items available.
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8.
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Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. [electronic resource] by
- Tuttle, Jamison B
- Anderson, Marie
- Bechle, Bruce M
- Campbell, Brian M
- Chang, Cheng
- Dounay, Amy B
- Evrard, Edelweiss
- Fonseca, Kari R
- Gan, Xinmin
- Ghosh, Somraj
- Horner, Weldon
- James, Larry C
- Kim, Ji-Young
- McAllister, Laura A
- Pandit, Jayvardhan
- Parikh, Vinod D
- Rago, Brian J
- Salafia, Michelle A
- Strick, Christine A
- Zawadzke, Laura E
- Verhoest, Patrick R
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 4
Availability: No items available.
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9.
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Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. [electronic resource] by
- Dounay, Amy B
- Anderson, Marie
- Bechle, Bruce M
- Campbell, Brian M
- Claffey, Michelle M
- Evdokimov, Artem
- Evrard, Edelweiss
- Fonseca, Kari R
- Gan, Xinmin
- Ghosh, Somraj
- Hayward, Matthew M
- Horner, Weldon
- Kim, Ji-Young
- McAllister, Laura A
- Pandit, Jayvardhan
- Paradis, Vanessa
- Parikh, Vinod D
- Reese, Matthew R
- Rong, SuoBao
- Salafia, Michelle A
- Schuyten, Katherine
- Strick, Christine A
- Tuttle, Jamison B
- Valentine, James
- Wang, Hong
- Zawadzke, Laura E
- Verhoest, Patrick R
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 3
Availability: No items available.
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10.
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Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. [electronic resource] by
- Zhang, Lei
- Balan, Gayatri
- Barreiro, Gabriela
- Boscoe, Brian P
- Chenard, Lois K
- Cianfrogna, Julie
- Claffey, Michelle M
- Chen, Laigao
- Coffman, Karen J
- Drozda, Susan E
- Dunetz, Joshua R
- Fonseca, Kari R
- Galatsis, Paul
- Grimwood, Sarah
- Lazzaro, John T
- Mancuso, Jessica Y
- Miller, Emily L
- Reese, Matthew R
- Rogers, Bruce N
- Sakurada, Isao
- Skaddan, Marc
- Smith, Deborah L
- Stepan, Antonia F
- Trapa, Patrick
- Tuttle, Jamison B
- Verhoest, Patrick R
- Walker, Daniel P
- Wright, Ann S
- Zaleska, Margaret M
- Zasadny, Kenneth
- Shaffer, Christopher L
Producer: 20140415
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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11.
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Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. [electronic resource] by
- Stepan, Antonia F
- Claffey, Michelle M
- Reese, Matthew R
- Balan, Gayatri
- Barreiro, Gabriela
- Barricklow, Jason
- Bohanon, Michael J
- Boscoe, Brian P
- Cappon, Gregg D
- Chenard, Lois K
- Cianfrogna, Julie
- Chen, Laigao
- Coffman, Karen J
- Drozda, Susan E
- Dunetz, Joshua R
- Ghosh, Somraj
- Hou, Xinjun
- Houle, Christopher
- Karki, Kapil
- Lazzaro, John T
- Mancuso, Jessica Y
- Marcek, John M
- Miller, Emily L
- Moen, Mark A
- O'Neil, Steven
- Sakurada, Isao
- Skaddan, Marc
- Parikh, Vinod
- Smith, Deborah L
- Trapa, Patrick
- Tuttle, Jamison B
- Verhoest, Patrick R
- Walker, Daniel P
- Won, Annie
- Wright, Ann S
- Whritenour, Jessica
- Zasadny, Kenneth
- Zaleska, Margaret M
- Zhang, Lei
- Shaffer, Christopher L
Producer: 20171016
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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