Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1-42)-induced rat model of Alzheimer's disease. [electronic resource]
Producer: 20140724Description: 146-58 p. digitalISSN:- 1029-2470
- Alzheimer Disease -- drug therapy
- Amyloid beta-Peptides
- Animals
- Antioxidants -- metabolism
- Apoptosis
- Apoptosis Regulatory Proteins -- metabolism
- Catalase -- metabolism
- Drug Evaluation, Preclinical
- Gene Expression -- drug effects
- Glutathione -- metabolism
- Glutathione Peroxidase -- metabolism
- Hippocampus -- drug effects
- Humans
- Lipid Peroxidation
- Male
- Malondialdehyde -- metabolism
- NF-kappa B -- genetics
- Neuroprotective Agents -- pharmacology
- Niacinamide -- pharmacology
- Oxidative Stress -- drug effects
- Peptide Fragments
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- genetics
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- metabolism
- Superoxide Dismutase -- metabolism
- Synaptosomes -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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