Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy. [electronic resource]
Producer: 20200226ISSN:- 2575-1077
- Aldosterone -- chemistry
- Animals
- Anti-Inflammatory Agents -- chemistry
- CRISPR-Associated Protein 9 -- genetics
- Cardiomyopathies -- drug therapy
- Computer Simulation
- Disease Models, Animal
- Eplerenone -- chemistry
- Gene Knockout Techniques
- Hydrogen Bonding
- Macrophages -- drug effects
- Mice
- Mice, Inbred C57BL
- Mineralocorticoid Receptor Antagonists -- chemistry
- Muscular Dystrophy, Duchenne -- drug therapy
- Myocarditis -- drug therapy
- Myocytes, Cardiac -- drug effects
- Prednisolone -- chemistry
- Pregnadienediols -- chemistry
- RAW 264.7 Cells
- Receptors, Glucocorticoid -- chemistry
- Receptors, Mineralocorticoid -- agonists
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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