Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes. [electronic resource]
Producer: 20060731Description: 950-4 p. digitalISSN:- 0090-9556
- Administration, Oral
- Adult
- Aged
- Cells, Cultured
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- biosynthesis
- Drug Evaluation, Preclinical -- methods
- Enzyme Induction
- Female
- Hepatocytes -- drug effects
- Humans
- Hydrocortisone -- analogs & derivatives
- Hydroxytestosterones -- metabolism
- Male
- Phthalazines -- administration & dosage
- Platelet Aggregation Inhibitors -- administration & dosage
- RNA, Messenger -- metabolism
- Recombinant Proteins -- metabolism
- Treatment Failure
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Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
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