Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. [electronic resource]
Producer: 20020819Description: 3394-405 p. digitalISSN:- 0022-2623
- Animals
- Antibodies -- pharmacology
- Binding Sites
- CD3 Complex -- immunology
- Crystallography, X-Ray
- Enzyme Inhibitors -- chemical synthesis
- Female
- Humans
- Imidazoles -- chemical synthesis
- Interleukin-2 -- biosynthesis
- Isoquinolines -- chemical synthesis
- Jurkat Cells
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck) -- antagonists & inhibitors
- Mice
- Mice, Inbred BALB C
- Models, Molecular
- Molecular Conformation
- Structure-Activity Relationship
- T-Lymphocytes -- drug effects
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Publication Type: Journal Article
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