Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition. [electronic resource]
Producer: 20181010Description: 512-521 p. digitalISSN:- 1476-5594
- Animals
- Antineoplastic Agents -- pharmacology
- Azepines -- pharmacology
- Benzodiazepines -- pharmacology
- Cell Cycle Proteins
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Resistance, Neoplasm -- genetics
- Enhancer Elements, Genetic -- genetics
- Epigenesis, Genetic
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Melanoma -- drug therapy
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Mitochondria -- drug effects
- Nuclear Proteins -- antagonists & inhibitors
- Patient Selection
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha -- genetics
- Protein Binding -- genetics
- SOXE Transcription Factors -- genetics
- Skin Neoplasms -- drug therapy
- Transcription Factors -- antagonists & inhibitors
- Treatment Outcome
- Triazoles -- pharmacology
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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