Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice. [electronic resource]
Producer: 20210402Description: 609-623 p. digitalISSN:- 1528-0012
- Animals
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor -- transplantation
- Disease Models, Animal
- Disease-Free Survival
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Neoplastic -- immunology
- Gene Knockdown Techniques
- Humans
- Immune Checkpoint Inhibitors -- pharmacology
- Liver -- pathology
- Liver Neoplasms -- drug therapy
- Male
- Mice
- Mice, Knockout
- Nectins -- genetics
- Nivolumab -- pharmacology
- Programmed Cell Death 1 Receptor -- antagonists & inhibitors
- Protein Stability
- Receptors, Immunologic -- antagonists & inhibitors
- Receptors, Virus -- metabolism
- Response Evaluation Criteria in Solid Tumors
- T-Lymphocytes, Cytotoxic -- drug effects
- Tumor Suppressor Protein p53 -- genetics
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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