The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo. [electronic resource]
Producer: 20100324Description: 3369-78 p. digitalISSN:- 1538-8514
- Animals
- Benzoquinones -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- HCT116 Cells
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- HT29 Cells
- Humans
- Hydroquinones -- metabolism
- Immunoblotting
- K562 Cells
- Lactams, Macrocyclic -- metabolism
- Male
- Mice
- Mice, Nude
- Mutation
- NAD(P)H Dehydrogenase (Quinone) -- genetics
- Neoplasms -- drug therapy
- Protein Binding
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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