Carbon monoxide releasing molecule A-1 attenuates acetaminophen-mediated hepatotoxicity and improves survival of mice by induction of Nrf2 and related genes. [electronic resource]
Producer: 20190426Description: 99-108 p. digitalISSN:- 1096-0333
- Acetaminophen -- adverse effects
- Animals
- Antioxidant Response Elements -- drug effects
- Antioxidants -- metabolism
- Carbon Monoxide -- pharmacology
- Cell Line, Tumor
- Chemical and Drug Induced Liver Injury -- drug therapy
- Glutathione -- metabolism
- Hep G2 Cells
- Humans
- Kelch-Like ECH-Associated Protein 1 -- metabolism
- Liver -- drug effects
- Liver Function Tests -- methods
- Male
- Mice
- Molecular Docking Simulation -- methods
- NF-E2-Related Factor 2 -- metabolism
- Oxidative Stress -- drug effects
- Signal Transduction -- drug effects
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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