Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity. [electronic resource]
Producer: 19940513Description: 4291-9 p. digitalISSN:- 0022-1767
- Animals
- Apoptosis -- drug effects
- CD4-Positive T-Lymphocytes -- drug effects
- Clonal Deletion -- drug effects
- Enterotoxins -- administration & dosage
- In Vitro Techniques
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred BALB C
- Pertussis Toxin
- Poly(ADP-ribose) Polymerases -- metabolism
- Receptors, Antigen, T-Cell, alpha-beta -- metabolism
- Spleen -- cytology
- Superantigens -- administration & dosage
- T-Lymphocyte Subsets -- drug effects
- T-Lymphocytes -- drug effects
- Virulence Factors, Bordetella -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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