Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. [electronic resource]
Producer: 20070208Description: 258-68 p. digitalISSN:- 0950-9232
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- genetics
- Animals
- Antifungal Agents -- pharmacology
- Blotting, Western
- Constitutive Androstane Receptor
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- genetics
- DNA-Binding Proteins -- antagonists & inhibitors
- Ethanol -- analogs & derivatives
- Female
- Gene Expression Regulation -- drug effects
- Hepatocytes -- metabolism
- Histone Acetyltransferases -- antagonists & inhibitors
- Humans
- Ketoconazole -- pharmacology
- Liver X Receptors
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nuclear Receptor Coactivator 1
- Orphan Nuclear Receptors
- Pregnane X Receptor
- RNA, Messenger -- metabolism
- Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors
- Receptors, Steroid -- antagonists & inhibitors
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors -- antagonists & inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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