HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair. [electronic resource]
Producer: 20080908Description: 1985-92 p. digitalISSN:- 1535-7163
- Ataxia Telangiectasia Mutated Proteins
- Benzoquinones -- pharmacology
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- DNA Repair -- drug effects
- DNA-Binding Proteins -- metabolism
- Down-Regulation -- drug effects
- Drug Screening Assays, Antitumor
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Lactams, Macrocyclic -- pharmacology
- Lung Neoplasms -- pathology
- Protein Serine-Threonine Kinases -- metabolism
- Radiation
- Radiation Tolerance -- drug effects
- Tumor Suppressor Protein p53 -- metabolism
- Tumor Suppressor Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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