Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptor. [electronic resource]
Producer: 20121221Description: 472-85 p. digitalISSN:- 1521-0103
- Alanine -- metabolism
- Animals
- Benzamides -- chemistry
- Binding Sites
- Cell Line, Transformed
- Diethylamines -- pharmacology
- HEK293 Cells
- Humans
- Ligands
- Membrane Proteins -- chemistry
- Mutation -- genetics
- Protein Binding -- drug effects
- Protein Structure, Secondary
- Rats
- Receptors, Dopamine D2 -- chemistry
- Receptors, Dopamine D4 -- chemistry
- Salicylamides -- pharmacology
- Sodium -- metabolism
- Structure-Activity Relationship
- Threonine -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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