Results
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1.
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Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold. [electronic resource] by
- Lou, Yan
- Sweeney, Zachary K
- Kuglstatter, Andreas
- Davis, Dana
- Goldstein, David M
- Han, Xiaochun
- Hong, Junbae
- Kocer, Buelent
- Kondru, Rama K
- Litman, Renee
- McIntosh, Joel
- Sarma, Keshab
- Suh, Judy
- Taygerly, Joshua
- Owens, Timothy D
Producer: 20150921
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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2.
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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. [electronic resource] by
- Simonetta, Kyle R
- Taygerly, Joshua
- Boyle, Kathleen
- Basham, Stephen E
- Padovani, Chris
- Lou, Yan
- Cummins, Thomas J
- Yung, Stephanie L
- von Soly, Szerenke Kiss
- Kayser, Frank
- Kuriyan, John
- Rape, Michael
- Cardozo, Mario
- Gallop, Mark A
- Bence, Neil F
- Barsanti, Paul A
- Saha, Anjanabha
Producer: 20190503
In:
Nature communications vol. 10
Availability: No items available.
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3.
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Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B. [electronic resource] by
- Schoenfeld, Ryan C
- Bourdet, David L
- Brameld, Ken A
- Chin, Elbert
- de Vicente, Javier
- Fung, Amy
- Harris, Seth F
- Lee, Eun K
- Le Pogam, Sophie
- Leveque, Vincent
- Li, Jim
- Lui, Alfred S-T
- Najera, Isabel
- Rajyaguru, Sonal
- Sangi, Michael
- Steiner, Sandra
- Talamas, Francisco X
- Taygerly, Joshua P
- Zhao, Junping
Producer: 20140310
In:
Journal of medicinal chemistry vol. 56
Availability: No items available.
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4.
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Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. [electronic resource] by
- Lou, Yan
- Han, Xiaochun
- Kuglstatter, Andreas
- Kondru, Rama K
- Sweeney, Zachary K
- Soth, Michael
- McIntosh, Joel
- Litman, Renee
- Suh, Judy
- Kocer, Buelent
- Davis, Dana
- Park, Jaehyeon
- Frauchiger, Sandra
- Dewdney, Nolan
- Zecic, Hasim
- Taygerly, Joshua P
- Sarma, Keshab
- Hong, Junbae
- Hill, Ronald J
- Gabriel, Tobias
- Goldstein, David M
- Owens, Timothy D
Producer: 20150427
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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5.
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Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity. [electronic resource] by
- Taygerly, Joshua P
- McGee, Lawrence R
- Rubenstein, Steven M
- Houze, Jonathan B
- Cushing, Timothy D
- Li, Yang
- Motani, Alykhan
- Chen, Jin-Long
- Frankmoelle, Walter
- Ye, Guosen
- Learned, Marc R
- Jaen, Juan
- Miao, Shichang
- Timmermans, Pieter B
- Thoolen, Martin
- Kearney, Patrick
- Flygare, John
- Beckmann, Holger
- Weiszmann, Jennifer
- Lindstrom, Michelle
- Walker, Nigel
- Liu, Jinsong
- Biermann, Donna
- Wang, Zhulun
- Hagiwara, Atsushi
- Iida, Tetsuya
- Aramaki, Hisateru
- Kitao, Yuki
- Shinkai, Hisashi
- Furukawa, Noboru
- Nishiu, Jun
- Nakamura, Motonao
Producer: 20130816
In:
Bioorganic & medicinal chemistry vol. 21
Availability: No items available.
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6.
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Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. [electronic resource] by
- Talamas, Francisco X
- Abbot, Sarah C
- Anand, Shalini
- Brameld, Ken A
- Carter, David S
- Chen, Jun
- Davis, Dana
- de Vicente, Javier
- Fung, Amy D
- Gong, Leyi
- Harris, Seth F
- Inbar, Petra
- Labadie, Sharada S
- Lee, Eun K
- Lemoine, Remy
- Le Pogam, Sophie
- Leveque, Vincent
- Li, Jim
- McIntosh, Joel
- Nájera, Isabel
- Park, Jaehyeon
- Railkar, Aruna
- Rajyaguru, Sonal
- Sangi, Michael
- Schoenfeld, Ryan C
- Staben, Leanna R
- Tan, Yunchou
- Taygerly, Joshua P
- Villaseñor, Armando G
- Weller, Paul E
Producer: 20140515
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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7.
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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. [electronic resource] by
- Caenepeel, Sean
- Brown, Sean P
- Belmontes, Brian
- Moody, Gordon
- Keegan, Kathleen S
- Chui, Danny
- Whittington, Douglas A
- Huang, Xin
- Poppe, Leszek
- Cheng, Alan C
- Cardozo, Mario
- Houze, Jonathan
- Li, Yunxiao
- Lucas, Brian
- Paras, Nick A
- Wang, Xianghong
- Taygerly, Joshua P
- Vimolratana, Marc
- Zancanella, Manuel
- Zhu, Liusheng
- Cajulis, Elaina
- Osgood, Tao
- Sun, Jan
- Damon, Leah
- Egan, Regina K
- Greninger, Patricia
- McClanaghan, Joseph D
- Gong, Jianan
- Moujalled, Donia
- Pomilio, Giovanna
- Beltran, Pedro
- Benes, Cyril H
- Roberts, Andrew W
- Huang, David C
- Wei, Andrew
- Canon, Jude
- Coxon, Angela
- Hughes, Paul E
Producer: 20191223
In:
Cancer discovery vol. 8
Availability: No items available.
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