Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists. [electronic resource]
Producer: 20200924Description: 4349-4369 p. digitalISSN:- 1520-4804
- Aminobiphenyl Compounds -- chemistry
- Animals
- Caco-2 Cells
- Drug Inverse Agonism
- HEK293 Cells
- Halogens -- chemistry
- Humans
- Male
- Molecular Docking Simulation -- methods
- Muscarinic Agonists -- chemistry
- Muscarinic Antagonists -- chemistry
- Protein Binding -- physiology
- Protein Structure, Secondary
- Rats
- Rats, Sprague-Dawley
- Receptor, Muscarinic M3 -- agonists
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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