The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. [electronic resource]
Producer: 20110328Description: 3210-20 p. digitalISSN:- 1538-8514
- Animals
- Bone Neoplasms -- complications
- Bone Resorption -- complications
- Bone and Bones -- diagnostic imaging
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Extremities -- pathology
- Histone Deacetylase Inhibitors -- chemistry
- Humans
- Hydroxamic Acids -- chemistry
- Mice
- Mice, SCID
- Osteolysis -- complications
- Radiography
- Tumor Burden -- drug effects
- Tumor Microenvironment -- drug effects
- Vorinostat
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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