Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC). [electronic resource]
Producer: 20170913Description: 329-339 p. digitalISSN:- 1768-3254
- Animals
- Antineoplastic Agents -- chemical synthesis
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- ErbB Receptors -- antagonists & inhibitors
- Gefitinib
- Humans
- Lung -- drug effects
- Lung Neoplasms -- drug therapy
- Mice
- Models, Molecular
- Morpholines -- chemical synthesis
- Point Mutation
- Protein Kinase Inhibitors -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Quinazolines -- pharmacology
- Xenograft Model Antitumor Assays
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.