Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway. [electronic resource]
Producer: 20111223Description: 385-92 p. digitalISSN:- 1875-5828
- Amyloid beta-Peptides -- drug effects
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Brain -- drug effects
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay -- methods
- Gene Expression Regulation -- drug effects
- Humans
- Mice
- Mice, Inbred C57BL
- RNA, Messenger -- metabolism
- Signal Transduction -- drug effects
- Sp1 Transcription Factor -- genetics
- Time Factors
- Transcription Factors -- genetics
- ortho-Aminobenzoates -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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