A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo. [electronic resource]
Producer: 20180222Description: e0191046 p. digitalISSN:- 1932-6203
- Animals
- Antibodies, Monoclonal -- immunology
- Antibodies, Monoclonal, Humanized
- Blotting, Western
- Colorectal Neoplasms -- enzymology
- Female
- HEK293 Cells
- Humans
- Immunoconjugates -- pharmacology
- Intestinal Mucosa -- enzymology
- Mice
- Mice, SCID
- Oligopeptides -- metabolism
- Receptors, Enterotoxin -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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