Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa). [electronic resource]
Producer: 20190130Description: 401-411 p. digitalISSN:- 1096-0929
- Animals
- Bile Acids and Salts -- blood
- Bile Ducts -- drug effects
- Bilirubin -- blood
- Biological Transport
- Cell Survival -- drug effects
- Clinical Trials, Phase I as Topic
- Cytochrome P-450 CYP3A -- genetics
- Hep G2 Cells
- Hepatocytes -- drug effects
- Humans
- Liver -- drug effects
- Macaca fascicularis
- Male
- Neuregulin-1 -- adverse effects
- Primary Cell Culture
- Toxicogenetics
- Transcriptome -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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