Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance. [electronic resource]
Producer: 20150521Description: 112-20 p. digitalISSN:- 1872-7980
- ATP Binding Cassette Transporter, Subfamily B -- genetics
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Proliferation -- drug effects
- Colorectal Neoplasms -- drug therapy
- Comparative Genomic Hybridization
- DNA Methylation -- drug effects
- Drug Resistance, Multiple -- drug effects
- Drug Resistance, Neoplasm -- drug effects
- Humans
- Promoter Regions, Genetic -- genetics
- Protein Kinase C -- antagonists & inhibitors
- Pyridines -- pharmacology
- RNA, Messenger -- genetics
- RNA, Small Interfering -- pharmacology
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Thiosemicarbazones -- pharmacology
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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