Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease. [electronic resource]
Producer: 20141117Description: 511-8 p. digitalISSN:- 1476-5578
- Age Factors
- Alzheimer Disease -- complications
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Arachidonate 5-Lipoxygenase -- genetics
- Brain -- pathology
- Conditioning, Classical -- drug effects
- Disease Models, Animal
- Excitatory Postsynaptic Potentials -- drug effects
- Fear -- psychology
- Gene Expression Regulation -- drug effects
- Humans
- Hydroxyurea -- analogs & derivatives
- In Vitro Techniques
- Lipoxygenase Inhibitors -- pharmacology
- Memory Disorders -- etiology
- Mice
- Mice, Transgenic
- Mutation -- genetics
- Presenilin-1 -- genetics
- Synapses -- drug effects
- tau Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
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