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Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors. [electronic resource] by
- Jaime-Figueroa, Saul
- De Vicente, Javier
- Hermann, Johannes
- Jahangir, Alam
- Jin, Sue
- Kuglstatter, Andreas
- Lynch, Stephen M
- Menke, John
- Niu, Linghao
- Patel, Vaishali
- Shao, Ada
- Soth, Michael
- Vu, Minh Diem
- Yee, Calvin
Producer: 20131108
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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5.
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Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome. [electronic resource] by
- Lynch, Stephen M
- DeVicente, Javier
- Hermann, Johannes C
- Jaime-Figueroa, Saul
- Jin, Sue
- Kuglstatter, Andreas
- Li, Hongju
- Lovey, Allen
- Menke, John
- Niu, Linghao
- Patel, Vaishali
- Roy, Douglas
- Soth, Michael
- Steiner, Sandra
- Tivitmahaisoon, Parcharee
- Vu, Minh Diem
- Yee, Calvin
Producer: 20131108
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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6.
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Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines. [electronic resource] by
- de Vicente, Javier
- Lemoine, Remy
- Bartlett, Mark
- Hermann, Johannes C
- Hekmat-Nejad, Mohammad
- Henningsen, Robert
- Jin, Sue
- Kuglstatter, Andreas
- Li, Hongju
- Lovey, Allen J
- Menke, John
- Niu, Linghao
- Patel, Vaishali
- Petersen, Ann
- Setti, Lina
- Shao, Ada
- Tivitmahaisoon, Parcharee
- Vu, Minh Diem
- Soth, Michael
Producer: 20150722
In:
Bioorganic & medicinal chemistry letters vol. 24
Availability: No items available.
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7.
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Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis. [electronic resource] by
- Lou, Yan
- Han, Xiaochun
- Kuglstatter, Andreas
- Kondru, Rama K
- Sweeney, Zachary K
- Soth, Michael
- McIntosh, Joel
- Litman, Renee
- Suh, Judy
- Kocer, Buelent
- Davis, Dana
- Park, Jaehyeon
- Frauchiger, Sandra
- Dewdney, Nolan
- Zecic, Hasim
- Taygerly, Joshua P
- Sarma, Keshab
- Hong, Junbae
- Hill, Ronald J
- Gabriel, Tobias
- Goldstein, David M
- Owens, Timothy D
Producer: 20150427
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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8.
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Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors. [electronic resource] by
- Lucas, Matthew C
- Bhagirath, Niala
- Chiao, Eric
- Goldstein, David M
- Hermann, Johannes C
- Hsu, Pei-Yuan
- Kirchner, Stephan
- Kennedy-Smith, Joshua J
- Kuglstatter, Andreas
- Lukacs, Christine
- Menke, John
- Niu, Linghao
- Padilla, Fernando
- Peng, Ying
- Polonchuk, Liudmila
- Railkar, Aruna
- Slade, Michelle
- Soth, Michael
- Xu, Daigen
- Yadava, Preeti
- Yee, Calvin
- Zhou, Mingyan
- Liao, Cheng
Producer: 20140527
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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9.
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3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead. [electronic resource] by
- Soth, Michael
- Abbot, Sarah
- Abubakari, Allassan
- Arora, Nidhi
- Arzeno, Humberto
- Billedeau, Roland
- Dewdney, Nolan
- Durkin, Kieran
- Frauchiger, Sandra
- Ghate, Manjiri
- Goldstein, David M
- Hill, Ronald J
- Kuglstatter, Andreas
- Li, Fujun
- Loe, Brad
- McCaleb, Kristen
- McIntosh, Joel
- Papp, Eva
- Park, Jaehyeon
- Stahl, Martin
- Sung, Man-Ling
- Suttman, Rebecca
- Swinney, David C
- Weller, Paul
- Wong, Brian
- Zecic, Hasim
- Gabriel, Tobias
Producer: 20110914
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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10.
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Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. [electronic resource] by
- Goldstein, David M
- Soth, Michael
- Gabriel, Tobias
- Dewdney, Nolan
- Kuglstatter, Andreas
- Arzeno, Humberto
- Chen, Jeffrey
- Bingenheimer, William
- Dalrymple, Stacie A
- Dunn, James
- Farrell, Robert
- Frauchiger, Sandra
- La Fargue, JoAnn
- Ghate, Manjiri
- Graves, Bradford
- Hill, Ronald J
- Li, Fujun
- Litman, Renee
- Loe, Brad
- McIntosh, Joel
- McWeeney, Daniel
- Papp, Eva
- Park, Jaehyeon
- Reese, Harlan F
- Roberts, Richard T
- Rotstein, David
- San Pablo, Bong
- Sarma, Keshab
- Stahl, Martin
- Sung, Man-Ling
- Suttman, Rebecca T
- Sjogren, Eric B
- Tan, Yunchou
- Trejo, Alejandra
- Welch, Mary
- Weller, Paul
- Wong, Brian R
- Zecic, Hasim
Producer: 20110606
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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11.
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3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models. [electronic resource] by
- Soth, Michael
- Hermann, Johannes C
- Yee, Calvin
- Alam, Muzaffar
- Barnett, Jim W
- Berry, Pamela
- Browner, Michelle F
- Frank, Karl
- Frauchiger, Sandra
- Harris, Seth
- He, Yang
- Hekmat-Nejad, Mohammad
- Hendricks, Than
- Henningsen, Robert
- Hilgenkamp, Ramona
- Ho, Hoangdung
- Hoffman, Ann
- Hsu, Pei-Yuan
- Hu, Dong-Qing
- Itano, Andrea
- Jaime-Figueroa, Saul
- Jahangir, Alam
- Jin, Sue
- Kuglstatter, Andreas
- Kutach, Alan K
- Liao, Cheng
- Lynch, Stephen
- Menke, John
- Niu, Linghao
- Patel, Vaishali
- Railkar, Aruna
- Roy, Douglas
- Shao, Ada
- Shaw, David
- Steiner, Sandra
- Sun, Yongliang
- Tan, Seng-Lai
- Wang, Sandra
- Vu, Minh Diem
Producer: 20130417
In:
Journal of medicinal chemistry vol. 56
Availability: No items available.
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