HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas. [electronic resource]
Producer: 20130409Description: 57 p. digitalISSN:- 1756-8722
- Aged
- Aged, 80 and over
- Apoptosis -- drug effects
- Cell Line, Tumor
- Female
- Humans
- Imidazoles -- pharmacology
- Indoles -- pharmacology
- Lymphoma, B-Cell -- drug therapy
- Male
- Middle Aged
- Piperazines -- pharmacology
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Spiro Compounds -- pharmacology
- Tumor Suppressor Protein p53 -- metabolism
- Ubiquitination -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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