LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. [electronic resource]
Producer: 19970409Description: 1116-23 p. digitalISSN:- 0008-5472
- 5,10-Methylenetetrahydrofolate Reductase (FADH2)
- Acyltransferases -- antagonists & inhibitors
- Aminohydrolases -- antagonists & inhibitors
- Antimetabolites, Antineoplastic -- pharmacology
- Folic Acid Antagonists -- pharmacology
- Formate-Tetrahydrofolate Ligase -- antagonists & inhibitors
- Glutamates -- chemistry
- Guanine -- analogs & derivatives
- Humans
- Hydroxymethyl and Formyl Transferases
- Methotrexate -- pharmacology
- Methylenetetrahydrofolate Dehydrogenase (NADP) -- antagonists & inhibitors
- Methylenetetrahydrofolate Reductase (NADPH2)
- Molecular Structure
- Multienzyme Complexes -- antagonists & inhibitors
- Oxidoreductases -- antagonists & inhibitors
- Pemetrexed
- Phosphoribosylaminoimidazolecarboxamide Formyltransferase
- Phosphoribosylglycinamide Formyltransferase
- Polyglutamic Acid -- pharmacology
- Quinazolines -- pharmacology
- Tetrahydrofolate Dehydrogenase -- drug effects
- Tetrahydrofolates -- pharmacology
- Thiophenes -- pharmacology
- Thymidylate Synthase -- antagonists & inhibitors
- Tumor Cells, Cultured -- drug effects
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Publication Type: Journal Article
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