A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis challenge. [electronic resource]
Producer: 20101112Description: 4341-55 p. digitalISSN:- 1098-5522
- Administration, Intranasal
- Animals
- Anti-Bacterial Agents -- pharmacology
- Bacterial Proteins -- genetics
- Bacterial Vaccines -- administration & dosage
- Cell Line
- Female
- Francisella tularensis -- genetics
- Gene Deletion
- Genetic Markers
- Humans
- Immunity, Cellular
- Immunity, Humoral
- Immunoglobulins -- metabolism
- Injections, Intradermal
- Mice
- Mice, Inbred BALB C
- Tularemia -- immunology
- Vaccines, Attenuated -- administration & dosage
- Virulence
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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