The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies. [electronic resource]
Producer: 20160105Description: 2316-29 p. digitalISSN:- 1476-5381
- Animals
- Aorta, Thoracic -- drug effects
- Binding Sites
- Dose-Response Relationship, Drug
- Enzyme Activation
- Enzyme Activators -- pharmacology
- Gemfibrozil -- pharmacology
- Guanylate Cyclase -- metabolism
- Heme -- metabolism
- Humans
- Hypolipidemic Agents -- pharmacology
- Male
- Molecular Docking Simulation
- Nitric Oxide -- metabolism
- Oxidation-Reduction
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- pharmacology
- Protein Structure, Tertiary
- Rats, Sprague-Dawley
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Recombinant Proteins -- metabolism
- Signal Transduction -- drug effects
- Soluble Guanylyl Cyclase
- Time Factors
- Vasodilation -- drug effects
- Vasodilator Agents -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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