Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. [electronic resource]
Producer: 20030411Description: 350-8 p. digitalISSN:- 0887-6924
- Acetylation
- Analysis of Variance
- Anti-Bacterial Agents -- pharmacology
- Antibiotics, Antineoplastic -- pharmacology
- Cell Differentiation
- Cell Survival
- Core Binding Factor Alpha 2 Subunit
- DNA Methylation
- DNA Modification Methylases -- antagonists & inhibitors
- DNA Primers
- DNA-Binding Proteins -- genetics
- Depsipeptides
- Gene Expression Regulation, Neoplastic -- drug effects
- Histones -- drug effects
- Humans
- Interleukin-3 -- genetics
- Neoplasm Proteins -- genetics
- Peptides, Cyclic
- Proto-Oncogene Proteins -- genetics
- RUNX1 Translocation Partner 1 Protein
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors -- genetics
- Transcription, Genetic -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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