Definition of formulation design space, in vitro bioactivity and in vivo biodistribution for hydrophilic drug loaded PLGA/PEO-PPO-PEO nanoparticles using OFAT experiments. [electronic resource]
Producer: 20150914Description: 65-80 p. digitalISSN:- 1879-0720
- Adsorption
- Animals
- Caco-2 Cells
- Camptothecin -- analogs & derivatives
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Dose-Response Relationship, Drug
- Drug Design
- Humans
- Hydrophobic and Hydrophilic Interactions
- Irinotecan
- Lactic Acid -- chemistry
- Male
- Nanoparticles -- chemistry
- Particle Size
- Polyethylene Glycols -- chemistry
- Polyglycolic Acid -- chemistry
- Polylactic Acid-Polyglycolic Acid Copolymer
- Propylene Glycols -- chemistry
- Rats
- Rats, Wistar
- Structure-Activity Relationship
- Surface Properties
- Time Factors
- Tissue Distribution
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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