Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases Potential relationship with the effect of bisphosphonates on osteoclasts. [electronic resource]
Producer: 20090709Description: 335-43 p. digitalISSN:- 1873-2968
- Adenosine Triphosphate -- analogs & derivatives
- Animals
- Binding Sites
- Chromatography, High Pressure Liquid
- DNA Ligases -- metabolism
- Diphosphates -- metabolism
- Diphosphonates -- pharmacology
- Diterpenes -- metabolism
- Hemiterpenes -- metabolism
- Mevalonic Acid -- analogs & derivatives
- Organophosphorus Compounds -- metabolism
- Osteoclasts -- drug effects
- Polyisoprenyl Phosphates -- metabolism
- Polyphosphates -- metabolism
- RNA Ligase (ATP) -- metabolism
- Sesquiterpenes -- metabolism
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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