Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. [electronic resource]
Producer: 20130212Description: 2508-16 p. digitalISSN:- 1476-5551
- Animals
- Antibiotics, Antineoplastic -- therapeutic use
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- drug effects
- Blotting, Western
- Dactinomycin -- therapeutic use
- Female
- Flow Cytometry
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- genetics
- Male
- Mice
- Mice, Inbred C57BL
- Mice, SCID
- Mice, Transgenic
- Myeloid Cell Leukemia Sequence 1 Protein
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- RNA, Messenger -- genetics
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Risk Factors
- Survival Rate
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
- Vidarabine -- analogs & derivatives
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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