Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome. [electronic resource]
Producer: 20160408Description: 1071-83 p. digitalISSN:- 2567-689X
- Adult
- Aged
- Animals
- Antibodies, Monoclonal -- immunology
- Antiphospholipid Syndrome -- immunology
- Carrier Proteins -- metabolism
- Caspase 1 -- metabolism
- Endosomes -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulin G -- immunology
- Inflammasomes -- blood
- Interleukin-1beta -- blood
- Leukocytes, Mononuclear -- cytology
- Lupus Erythematosus, Systemic -- immunology
- Male
- Membrane Glycoproteins -- metabolism
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Monocytes -- cytology
- NADPH Oxidase 2
- NADPH Oxidases -- metabolism
- NLR Family, Pyrin Domain-Containing 3 Protein
- Reactive Oxygen Species
- Spleen -- metabolism
- Superoxides -- chemistry
- Thrombosis
- Toll-Like Receptor 2 -- metabolism
- Toll-Like Receptor 4 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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