Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists. [electronic resource]
Producer: 20160202Description: 8292-308 p. digitalISSN:- 1520-4804
- Acetates -- chemical synthesis
- Animals
- Antipsychotic Agents -- chemical synthesis
- Area Under Curve
- Dogs
- Drug Design
- Female
- Glucuronides -- metabolism
- Macaca fascicularis
- Male
- Mice
- Microsomes, Liver -- drug effects
- Phosphodiesterase Inhibitors -- chemical synthesis
- Phosphoric Diester Hydrolases -- drug effects
- Prodrugs
- Psychoses, Substance-Induced -- drug therapy
- Pyridones -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
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Publication Type: Journal Article
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