Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation. [electronic resource]
Producer: 20170328Description: 58-65 p. digitalISSN:- 1879-3169
- Alanine Transaminase -- blood
- Animals
- Biomarkers -- blood
- CD2 Antigens -- genetics
- Chemical and Drug Induced Liver Injury -- blood
- Chemokine CXCL2 -- genetics
- Concanavalin A
- Cytoprotection
- Disease Models, Animal
- Gene Expression Regulation
- Immunosuppressive Agents -- pharmacology
- Liver -- drug effects
- Male
- Mice, Inbred C57BL
- Mice, Knockout
- Neutrophil Infiltration -- drug effects
- Pregnane X Receptor
- Pregnenolone Carbonitrile -- pharmacology
- Receptors, Steroid -- agonists
- Signal Transduction -- drug effects
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Publication Type: Journal Article
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