Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. [electronic resource]
Producer: 20190909Description: 1052-1068 p. digitalISSN:- 1524-4571
- Activating Transcription Factor 6 -- biosynthesis
- Animals
- Cardiomyopathy, Hypertrophic -- metabolism
- Cells, Cultured
- Extracellular Matrix Proteins -- metabolism
- Fibroblasts -- metabolism
- Fibrosis -- metabolism
- Gene Expression Regulation
- Heart Failure -- chemically induced
- Humans
- Isoproterenol -- toxicity
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Myocardium -- metabolism
- NADPH Oxidase 4 -- biosynthesis
- NIH 3T3 Cells
- Oxidation-Reduction
- Protein Disulfide-Isomerases -- antagonists & inhibitors
- Protein Folding
- RNA Interference
- RNA, Small Interfering -- pharmacology
- Thioredoxins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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