A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. [electronic resource]
Producer: 20140310Description: 5553-61 p. digitalISSN:- 1520-4804
- Animals
- Area Under Curve
- Blotting, Western
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- HCT116 Cells
- Humans
- Indoles -- chemistry
- Inhibitory Concentration 50
- Kinetics
- Mice
- Microsomes -- metabolism
- Molecular Structure
- Neoplasms -- metabolism
- Oxindoles
- Protein Binding -- drug effects
- Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Spiro Compounds -- chemistry
- Tumor Suppressor Protein p53 -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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