Gene therapy with RNAi targeting UHRF1 driven by tumor-specific promoter inhibits tumor growth and enhances the sensitivity of chemotherapeutic drug in breast cancer in vitro and in vivo. [electronic resource]
Producer: 20120727Description: 1079-87 p. digitalISSN:- 1432-0843
- Animals
- Antineoplastic Agents -- pharmacology
- Breast Neoplasms -- drug therapy
- CCAAT-Enhancer-Binding Proteins -- deficiency
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Cisplatin -- pharmacology
- Combined Modality Therapy
- DNA Methylation
- Down-Regulation
- Female
- Gene Expression
- Genetic Therapy -- methods
- Humans
- Male
- Mice
- Mice, Nude
- Promoter Regions, Genetic
- RNA, Small Interfering -- administration & dosage
- Transfection
- Ubiquitin-Protein Ligases
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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