Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer's disease. [electronic resource]
Producer: 20020307Description: 1140-5 p. digitalISSN:- 0027-8424
- Alzheimer Disease -- metabolism
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases -- drug effects
- Cattle
- Cyclin-Dependent Kinase 5
- Cyclin-Dependent Kinases -- drug effects
- Enzyme Activation
- Estradiol -- pharmacology
- Estrogen Replacement Therapy
- Female
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Hot Temperature
- Humans
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinases -- metabolism
- Ovariectomy
- Phosphorylation
- Rats
- Rats, Sprague-Dawley
- Testosterone -- pharmacology
- tau Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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