TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling. [electronic resource]
Producer: 20201231Description: 2 p. digitalISSN:- 2040-2392
- CRISPR-Cas Systems
- Codon, Nonsense
- Eukaryotic Initiation Factor-4E -- metabolism
- Gene Editing
- Germ-Line Mutation
- Humans
- Induced Pluripotent Stem Cells -- cytology
- Intracellular Signaling Peptides and Proteins -- metabolism
- Mechanistic Target of Rapamycin Complex 1 -- antagonists & inhibitors
- Neural Stem Cells -- metabolism
- Neurogenesis
- Phenotype
- Protein Serine-Threonine Kinases -- metabolism
- RNA-Seq
- Signal Transduction
- Sirolimus
- Tuberous Sclerosis
- Tuberous Sclerosis Complex 1 Protein -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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