A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway. [electronic resource]
Producer: 20130424Description: 59-67 p. digitalISSN:- 1872-7980
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Carcinogenicity Tests
- Cell Line, Tumor
- Cyclin B1 -- metabolism
- Female
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Imidazoles -- pharmacology
- Male
- Mice
- Mice, Inbred BALB C
- Neovascularization, Pathologic -- drug therapy
- Phosphatidylinositol 3-Kinase -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Pyridines -- pharmacology
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Vascular Endothelial Growth Factor A -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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